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One patient. One continuous neuromuscular journey.


Neuromuscular management changes throughout every case. The information clinicians need during induction is different from what they need during maintenance, reversal, and recovery.

Powered by EMGINE™, TetraGraph transforms quantitative EMG data into intelligent, patient-specific information across four critical stages of care:

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01 — READINESS
Assess Intubation Readiness

Objective insight before intubation.

The TetraGraph Intubation Readiness Indicator uses the T1/Tc ratio to quantify suppression of the first twitch relative to control, providing objective insight into neuromuscular block depth during induction and supporting informed timing of tracheal intubation.

  • Intubation Readiness Indicator
  • T1/Tc measurement
  • Objective assessment of block depth
  • Quantitative EMG monitoring from induction
     
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02 — MANAGEMENT
Support Personalized Dosing Decisions

Stay aligned with the patient—and the surgical plan.

During maintenance, patient response, surgical requirements, and workflow can change quickly. TetraGraph continuously measures neuromuscular function while intelligent automation and personalized case prompts help clinicians manage block throughout the procedure.

  • Personalized case notifications
  • Level-of-Block Gauge™
  • Automatic PTC
  • Automatic Time Interval
  • Continuous signal-quality validation
  • Guided Signal Strength feedback
  • Single-Twitch and TOF monitoring
     
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03 — PREDICTION
Anticipate the Next 15 Minutes

From monitoring what has happened to anticipating what comes next.

Predictive Recovery provides an at-a-glance indication of whether a patient is likely to recover to TOFR ≥0.90 without reversal within the next 15 minutes, helping clinicians personalize recovery planning and make more informed reversal decisions.

Predict recovery. Consider reversal. Or wait and reassess.

  • Predictive Recovery
  • 15-minute recovery horizon
  • At-a-glance recovery status
  • Support for personalized reversal decisions
     
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04 — RECOVERY SAFETY
Confirm. Summarize. Close the Loop.

Prove recovery before the case ends.

Confirm quantitative recovery to TOFR ≥0.90, then close the case with a concise end-of-case summary including the trend overview, total case time, and TOFR when monitoring was paused or stopped.

From readiness to recovery, TetraGraph helps tell the complete neuromuscular management patient journey. 

  • TOFR ≥0.90 confirmation
  • End-of-case summary
  • Case trend overview
  • Total monitoring time
  • Objective documentation of recovery
     

Smart automation throughout the case

EMGINE™ integrates intelligent automation into the neuromuscular monitoring workflow—helping clinicians optimize signal quality, reduce manual adjustments, and maintain reliable monitoring from induction through recovery.

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Welcome to the next-generation TetraGraph era

Built on decades of science and powered by EMGINE™, next-generation TetraGraph combines advanced EMG algorithms, real-world data, and the proprietary Level-of-Block Gauge™ to deliver intelligent, personalized neuromuscular monitoring from induction through recovery.

WHY TETRAGRAPH?
Built on EMG. Powered by EMGINE™

Next-generation TetraGraph combines advanced electromyography with the EMGINE™ software platform to deliver precise, reliable neuromuscular measurements and intelligent software-driven insights throughout the perioperative continuum.

Its advanced EMG algorithm has been refined using more than six billion real-world data points and analyzes muscle function at four times higher resolution compared with TetraGraph Classic.

Algorithms help optimize signal strength and automate monitoring workflows from induction through recovery.

High-resolution quantitative measurements across all levels of neuromuscular block.

The proprietary Level-of-Block Gauge™ turns complex quantitative information into an easy-to-interpret view of the patient's current state and trend.

Portable design, flexible mounting, EMG sensors for diverse patients and connectivity to supported multiparameter monitors and EHR infrastructure.

TetraGraph in the OR

Intuitive interface for enhanced clarity

TetraGraph features an intuitive interface, so clinicians can easily view and analyze patient data trends, enhancing decision-making and patient management throughout the perioperative period, including both real-time and post-procedure reviews.

Smart and versatile patient monitoring

Designed with versatility in mind, TetraGraph effortlessly adapts to any operating room environment. It connects seamlessly with external multiparameter monitors and electronic health records (EHR), maximizing efficiency and enhancing patient care. 

Our flexible EMG sensors and mounting options accommodate various surgical procedures, including those with space and movement limitations like tucked-arm and robotic cases.

Visit Next-Generation TetraGraph connectivity solutions

TetraSens sensor
TetraSens for adults

Adaptable for adult patients, ensuring precise neuromuscular monitoring for a wide range of surgical applications.

TetraSens sensor
TetraSens Pediatric for pediatrics

Ultrasoft, flexible material and FDA-cleared EMG sensor with a specific pediatric indication, streamlining one sensor for infants to adolescents. 

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Next-generation TetraGraph vs. other EMG devices
 TetraGraph EMGOther EMG devices
Clinically validated at all levels of block, including deep and profound blocks YesNo
Proprietary Level-of-Block Gauge™ for easy-to-interpret, high-resolution, real-time display of individual EMG readings, waveforms (CMAPs) and trendsYesNo
TetraGraph Series of Algorithms, powered by EMGINE, aids in signal strength optimization, intubation readiness, and predictive recovery, providing objective data throughout the caseYesNo
Backed by over 40 years of research, and developed with insights from global leaders in anesthesiologyYesNo
Advanced EMG algorithm with 4 times higher resolution when compared to TetraGraph Classic, superior artifact handling, and noise cancellation without the need for extra (ground) electrodes.YesNo
Complete sensor portfolio, from infants to adults with sensitive skinYesNo

Choosing the right TOF monitor?

Our buyer's guide compares quantitative and qualitative monitoring technologies, outlines five essential evaluation criteria, and quantifies the impact on patient outcomes and total cost of care.

Clinical Validation

Evidence You Can Trust Across the Neuromuscular Management Journey

TetraGraph® is supported by clinical evidence demonstrating accurate, consistent quantitative EMG measurements across all levels of neuromuscular block—from deep block through recovery—and supporting informed clinical decisions throughout the case. 

Assess Intubation Readiness with Objective Data

Quantitative monitoring can support better-informed timing of tracheal intubation.

In a 2026 randomized prospective study, 73% of patients in the TetraGraph-monitored group achieved ideal intubating conditions compared with 57% in the standard time-based group (p=0.036).

The study also demonstrated an association between greater first-twitch suppression and improved intubating conditions, supporting the use of quantitative neuromuscular monitoring to objectively assess block depth during induction.


Reference: Renew JR, et al. Journal of Clinical Anesthesia. 2026;108:112066.

Validated Across All Levels of Block

Accuracy from deep neuromuscular block through recovery.

TetraGraph EMG has been clinically validated against mechanomyography (MMG) across TOF ratio, TOF count, and post-tetanic count measurements, demonstrating strong correlation with the clinical reference standard, including during deep neuromuscular block. 

Reference: Ebert TJ, et al. Journal of Clinical Monitoring and Computing. 2024.

Precise Quantitative Recovery Assessment

Confidence when confirming recovery matters most.

A 2024 study published in Anesthesiology comparing quantitative neuromuscular monitors with mechanomyography demonstrated that TetraGraph produced baseline TOF-ratio measurements closely aligned with the reference standard, reinforcing its accuracy and precision for quantitative neuromuscular monitoring.

Reference: Wedemeyer Z, et al. Anesthesiology. 2024.

Built on Decades of Neuromuscular Monitoring Research

TetraGraph combines clinically validated EMG technology with advanced algorithms designed to deliver reliable quantitative information throughout neuromuscular management, from readiness for intubation through confirmation of recovery.

TetraGraph 90 TOFR
Navigate the new frontier of advancing beyond the twitch
Experience personalized neuromuscular management.

From intubation readiness to recovery safety, discover how next-generation TetraGraph powered by EMGINE™ supports informed decisions throughout the patient journey.

Predict. Prove. Protect.
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TetraAnalytics

 

Turn neuromuscular monitoring data into actionable clinical and operational insights.

TetraAnalytics™ is an adjunct solution to TetraGraph® that securely transfers monitoring data to the cloud, transforming patterns across cases into actionable insights that can improve patient safety, outcomes, workflows, and economics.

With intuitive dashboards and key performance metrics, TetraAnalytics helps organizations evaluate neuromuscular block management at scale, monitor adherence to clinical guidelines, identify trends, and measure improvement over time.

Key benefits:

  • Monitor adherence to quantitative neuromuscular monitoring best practices
  • Identify trends and opportunities across cases
  • Track key clinical and operational metrics over time
  • Support workflow optimization and quality improvement
  • Turn TetraGraph data into actionable organizational insights

Explore TetraAnalytics

Explore TetraGraph resources
Product brochure

A complete overview of the next-generation TetraGraph, including tech specs

TetraGraph Trend Views one-pager

Three unique trend views to elevate clinical confidence

Contact us to get started!

Note:  The TetraGraph system is available in the United States through 510(k) clearance. It is also available in Australia and Japan. In the European Economic Area (EEA), it is available with CE certification, subject to local language translation requirements. For availability in other regions, please contact us. 

TetraGraph is a widely studied system
  • Nazira W, Villalobosa EE, Padillaa SP, Mavesa G, Tobias JD, Quantitative Train-of-Four Monitoring Using the TetraGraph to Evaluate Rocuronium Requirements During Renal Transplantation in a Pediatric Patient, J Med Cases. 2025;16(9):331-336
  • Danielsons S, Welter J, Dullenkopf A, 2025, Observational Cohort Study of TetraGraph® Electromyography Compared to Standard Acceleromyography Monitoring, Journal of clinical medicine - Volume 14, Issue 17, pp
  • Chaney A, Villalobos EE, Rice-Weimer J, Tobias JD, Intraoperative Electromyographic Monitoring in Children Less Than 1 Year of Age, Paediatric anaesthesia - Volume 35, Issue 11, pp. 934-939
  • Werner, Sarah J., Georgevici, Adrian I., Weber, Thomas P., Klutzny, Mitja, Dencks, Stefanie, Oblisz, Nico, Gude, Philipp, Herzog-Niescery, Jennifer, Quantifying the effect of succinylcholine on vocal cord opening using electromyographic single twitch for facilitated mask ventilation: a prospective observational study, Trends in Anaesthesia and Critical Care - Volume 62, Issue 0, pp. 101564
  • Herzog-Niescery J, von der Gönna M, Werner S, Weber T and Georgevici A, The electromyographic single twitch stimulation for monitoring the effect of rocuronium on vocal cord opening – a randomised controlled trial
  • Asztalos L, Boktor M, Kukuly M, Sólyom D, Pongrácz A, Brull S, Fülesdi B, The Relationship Between Neuromuscular Block Depth and Airway Retroglossal Area: A Prospective, Nonrandomized, Observational Clinical Trial
  • Hernandez V, Chaves-Cardona H, Rivero A, Matus M, Logvinov I, Brull S, Renew J, Comparison of adductor pollicis and flexor hallucis brevis muscle electromyographic responses: a prospective cohort study
  • Fülesdi B, Luterán P, Boktor M, Asztalos L, Nagy G, Brull SJ, Molnár C. Time Course of a Single, 0.6 mg/kg Dose of Rocuronium Neuromuscular Block During Sevoflurane or Propofol Anesthesia in Infants—A Prospective, Randomized Trial. Journal of Clinical Medicine. 2025; 14(18):6459.
  • Wedemeyer Z, Michaelsen KE, Jelacic S, Silliman W, Lopez A, Togashi K, Bowdle A Accuracy and Precision of Three Acceleromyographs, Three Electromyographs, and a Mechanomyograph Measuring the Train-of-four Ratio in the Absence of Neuromuscular Blocking Drugs Anesthesiology - Volume 141, Issue 2, pp. 262-271 2024.
  • Epstein RH, Nemes R, Renew JR, Brull SJ Area under the curve and amplitude of the compound motor action potential are clinically interchangeable quantitative measures of neuromuscular block: a method comparison study BJA open - Volume 11, Issue , pp. 100293 – 2024.
  • Ebert TJ, Vogt JA, Kaur R, Iqbal Z, Peters DJ, Cummings CE, Stekiel TA. Train-of-four ratio, counts and post tetanic counts with the TetraGraph electromyograph in comparison to mechanomyography. Journal of clinical monitoring and computing - Volume , Issue , pp. Online ahead of print - 2024
  • Tobias JD, Epstein RH, Rice-Weimer J, Yemele Kitio SA, Brull SJ, Kalsotra S. Pediatric Intraoperative Electromyographic Responses at the Adductor Pollicis and Flexor Hallucis Brevis Muscles: A Prospective, Comparative Analysis. Anesthesia and analgesia - Volume 139, Issue 1, pp. 36-43 - 2024
  • Haberkorn S, Twite M, Klockau K, Whitney G, Faulk DJ. Quantitative Monitoring Maximizes Cost-Saving Strategies When Antagonizing Neuromuscular Block With Sugammadex. Cureus - Volume 16, Issue 9, pp. e68551 -2024
  • Espinal LM, Kalsotra S, Rice-Weimer J, Kitio SAY, Tobias JD. Tolerance to preoperative placement of electrodes for neuromuscular monitoring using the TetraGraph. Saudi journal of anaesthesia - Volume 18, Issue 2, pp. 205-210 – 2024
  • Verdonck M, Carvalho H, Fuchs-Buder T, Brull SJ, Poelaert J. Machine learning based analysis and detection of trend outliers for electromyographic neuromuscular monitoring. Journal of clinical monitoring and computing - Volume 38, Issue 5, pp. 1163-1173, 2024
  • Kalsotra et al, 2023 Intraoperative electromyographic monitoring in children using a novel pediatric sensor. Saudi journal of anaesthesia - Volume 17, Issue 3, pp. 378-382 - published 2023-07-01
  • Chaves-Cordona et al, 2023 Comparison of onset of neuromuscular blockade with electromyographic and acceleromyographic monitoring: a prospective clinical trial. Brazilian journal of anesthesiology (Elsevier) - Volume 73, Issue 4, pp. 393-400 - published 2023-07-01
  • Renew et al, 2023 Comparison of visual and electromyographic assessments with train-of-four stimulation of the ulnar nerve: a prospective cohort study. Canadian journal of anaesthesia - Volume 70, Issue 5, pp. 878-885 - published 2023-05-01
  • Iwasaki et al, 2023 The impact of electrosurgical devices on electromyography-based neuromuscular monitoring during abdominal laparotomy: a case series. Journal of clinical monitoring and computing - Volume 37, Issue 4, pp. 1111-1114 - published 2023-08-01.
  • Owuso-Bediako et al, 2022, Feasibility of intraoperative quantitative neuromuscular blockade monitoring in children using electromyography Saudi J Anaesth. 2022 Oct-Dec; 16(4): 412–418.
  • Sato et al. Comparison of two electromyography-based neuromuscular monitors, AF-201P and TetraGraph, in rocuronium-induced neuromuscular block: A prospective comparative study. Anaesth Crit Care Pain Med. 2022 Aug 31;41(6):101145
  • Iwasaki et al. A Comparison Between the Adductor Pollicis Muscle Using TOF-Watch SX and the Abductor Digiti Minimi Muscle Using TetraGraph in Rocuronium-Induced Neuromuscular Block: A Prospective Observational Study. Anesth Analg. 2022 Aug 1;135(2):370-375
  • Giorgio Giudici, Federico Piccioni, Paolo Proto, Franco Valenza, A comparison of accelerometric monitoring by TOF Watch® SX and electromyographic monitoring by TetraGraph for recovery from neuromuscular blockade, Journal of Clinical Anesthesia, Volume 75, 2021,110481
  • Nemes, R, Lengyel, S, Nagy, G., Hampton, D.R., Gray, M, Renew J.R., Tassonyi, E, Fülesdi, B, Brull S.J., Ipsilateral and Simultaneous Comparison of Responses from Acceleromyography- and Electromyography-based Neuromuscular Monitors. Anesthesiology, 2021, Newly published on July 30
  • Renew JR, Hernandez-Torres V, Logvinov I, Nemes R, Nagy G, Li Z, Watt L, Murphy GS, Comparison of the TetraGraph and TOFscan for monitoring recovery from neuromuscular blockade in the Post Anesthesia Care Unit., J Clin Anesth, 2021, Aug;71:110234
  • Renew JR, Hex K, Johnson P, Lovett P, Pence R. Ease of Application of Various Neuromuscular Devices for Routine Monitoring. Anesth Analg. 2021 May 1;132(5):1421-1428. Nemes R, Nagy G, Murphy GS, Logvinov II, Fülesdi B, Renew JR. Awake Volunteer Pain Scores During Neuromuscular Monitoring. Anesth Analg. 2020 Apr;130(4):941-948.  

Abstracts with TetraGraph

  • S Paredes, A Smith, L Puertas-Ocio, E villalobos, W Nazir, S A Y Kitio, J Rice-Weimer, J D Tobias, Train-of-four monitoring using (TetraGraph ) to evaluate rocuronium infusion requirements during major surgery, 2025
  • Villalobos 2025 - Intraoperative Neuromuscular Monitoring Electromyography Monitor vs. PNS- Does the Face Lie
  • A Chaney, E Villalobos, J Rice-Weimer, J.D. Tobias, Intraoperative electromyographic monitoring in children less than 1 year of age 2025
  • S Waite, P Raju, G Rodney, Measurement of System Usability- validating the system usability score within anaesthesia 2024
  • J Herzog-Niescery, S Werner, S Dencks, T Weber, A Georgevici, Quantifizierung de suciinylcholin-Wirkung auf die Stimmbandöffnungsfläche mittels electromyografischem signle twitch monitoring, 2024
  • E Villalobos, S padilla, Sj Brull, J Tobias, Intraoperative Neuromuscular Monitoring: Electromyography Monitor Versus Peripheral Nerve Stimulator – Does the Face Lie? A Case Report.2024
  • P Frykholm, Delayed onset of atracurium detected by neuromuscular monitoring with the TetraGraph paediatric electrodes. First experience with a new device in small children.2024
  • S Haberkorn, M Twite, K Klockau, G Whitey, A Quality Improvement Project to Reduce Sugammadex Cost and Waste by Using Aliquots and Quantitative Neuromuscular Monitoring SPA 2023
  • R Kaur, J vogt, E Shibly, D peters, Z Iqbal, S Gandhi, T Ebert, Validation clinical important neuromuscular monitoring endpoints: Mechanomyography vs. electromyograph IARS 2023
  • RH Epstein, R Nemes, JR Renew, SJ Brull, Optimization of the Timing of Laryngoscopy Using Quantitative Neuromuscular Blockade Monitoring: An Exploratory Analysis, Anesthesiology 2022.
  • P Majou, C Meistelman, S Brull Comparison of the TOFscan and the TetraGraph during recovery of neuromuscular block : a pilot study, 2022
  • J Renew, V Hernandez-Torres, R Nemes, G Murphy, Multicenter study comparing the ToFscan and TetraGraph during Recovery of Neuromuscular Function in the Post Anesthesia Care Unit 2021
  • R Munch, J Mathias, J Tobias, K Owusu-Bediako, Characteristics of quantitative train-of-four monitoring in children using electromyography.
  • L Puertas-Ocio, J Tobias, K Owusu-Bediako. Intraoperative pediatric neuromuscular monitoring in laparoscopic (restricted arm access) surgical setting.
  • K Owusu-Bediako, S Kim, J Rice-Weimer, J Tobias, Feasibility Of Pediatric Neuromuscular Monitoring In Laparoscopic (restricted Arm Movement) Surgical Settings
  • M Twite, B Smith, R Ing. The use of Quantitative Neuromuscular Monitoring to Understand Neuromuscular Blockade, Re-dosing, Reversal and Residual Blockade in Children undergoing Cardiac Catheterization Procedures
  • K Owusu-Bediako, S Kim, J Rice-Weimer, J Tobias, Quantitative Train-of-four Monitoring In Pediatric Patients Using Electromyography. Anesthesiology 2021.
  • V Hernandez, H Chaves-Cardona, A Rivero, M Matus, JR Renew, SJ Brull. Comparison of adductor pollicis and flexor hallucis brevis muscles (thumb vs. great toe) as sites for neuromuscular monitoring with electromyography after sugammadex antagonism. Anesthesiology 2021
  • V Hernandez, H Chaves-Cardona, M Restrepo-Holguin, JR Renew, SJ Brull. Electromyography for the detection of residual neuromuscular block in clinical practice: a systematic review and meta-analysis. Anesthesiology 2021.
  • JR Renew, V Hernandez-Torres, R Pence, SJ Brull. Comparison of visual and electromyography assessments in response to train-of-four stimulation of the ulnar nerve. Anesth Analg. Presented IARS 2021.
  • V Hernandez, H Chaves-Cardona, JR Renew, SJ Brull. Electromyographic And Acceleromyographic Monitoring In Restricted Arm Movement Surgical Setting. A Prospective, Randomized Trial. Anesthesiology 2021; A2069
  • A Creighton, D Kim, S Liang, P A Stewart, Comparison of two muscles using a novel electromyographic device to assess recovery from muscle relaxants in patients undergoing general anaesthesia. ASA NCS 2019
  • R Nemes, J. Renew Comparison of Electromyography Derived Train-Of-Four Ratios of the Adductor Pollicis and Abductor Digiti Minimi Muscles and Their Comparison to Acceleromyography Derived Train-Of-Four Ratios, STA meeting
  • J Renew , A Donaldson , I Logvinov , R Chadha , R McClain , R Nemes, Comparative Investigation Of AMG- And EMG-Based Neuromuscular Monitors, P-9113, 2018 NY PGA